4LSQ

Crystal structure of broadly and potently neutralizing antibody VRC-CH31 in complex with HIV-1 clade A/E gp120 93TH057 with LOOP D and Loop V5 from clade A strain 3415_v1_c1

4LSQ の概要

• エントリーDOI: 10.2210/pdb4lsq/pdb
• 関連するPDBエントリー: 3NGB 3SE8 3SE9 4J6R 4JB9 4JPV 4JPW
• 分子名称: ENVELOPE GLYCOPROTEIN GP120 WITH LOOP D AND V5 FROM STRAIN 3415_V1_C1, HEAVY CHAIN OF ANTIBODY VRC-CH31, LIGHT CHAIN OF ANTIBODY VRC-CH31 WITH N70D MUTATION, ... (9 entities in total)
• 機能のキーワード: neutralizing antibody vrc-ch31, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Human immunodeficiency virus 1; 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 90449.76

構造登録者

Zhou, T.,Moquin, S.,Kwong, P.D. (登録日: 2013-07-23, 公開日: 2013-08-21, 最終更新日: 2020-07-29)

• 主引用文献: Zhou, T.,Zhu, J.,Wu, X.,Moquin, S.,Zhang, B.,Acharya, P.,Georgiev, I.S.,Altae-Tran, H.R.,Chuang, G.Y.,Joyce, M.G.,Do Kwon, Y.,Longo, N.S.,Louder, M.K.,Luongo, T.,McKee, K.,Schramm, C.A.,Skinner, J.,Yang, Y.,Yang, Z.,Zhang, Z.,Zheng, A.,Bonsignori, M.,Haynes, B.F.,Scheid, J.F.,Nussenzweig, M.C.,Simek, M.,Burton, D.R.,Koff, W.C.,Mullikin, J.C.,Connors, M.,Shapiro, L.,Nabel, G.J.,Mascola, J.R.,Kwong, P.D.; Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies.; Immunity, 39:245-258, 2013; PubMed: 23911655; DOI: 10.1016/j.immuni.2013.04.012

実験手法

X-RAY DIFFRACTION (2.25 Å)