4LRG
Structure of BRD4 bromodomain 1 with a dimethyl thiophene isoxazole azepine carboxamide
Summary for 4LRG
Entry DOI | 10.2210/pdb4lrg/pdb |
Related | 4LR6 |
Descriptor | Bromodomain-containing protein 4, 2-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-[1,2]oxazolo[5,4-c]thieno[2,3-e]azepin-6-yl]acetamide (3 entities in total) |
Functional Keywords | bet inhibitor, brd4 first bromodomain, transcription regulator-inhibitor complex, transcription regulator/inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: O60885 |
Total number of polymer chains | 1 |
Total formula weight | 15526.23 |
Authors | Ravichandran, S.,Jayaram, H.,Poy, F.,Gehling, V.,Hewitt, M.,Vaswani, R.,Leblanc, Y.,Cote, A.,Nasveschuk, C.,Taylor, A.,Harmange, J.-C.,Audia, J.,Pardo, E.,Joshi, S.,Sandy, P.,Mertz, J.,Sims, R.,Bergeron, L.,Bryant, B.,Yellapuntala, S.,Nandana, B.S.,Birudukota, S.,Albrecht, B.,Bellon, S. (deposition date: 2013-07-19, release date: 2013-08-07, Last modification date: 2024-02-28) |
Primary citation | Gehling, V.S.,Hewitt, M.C.,Vaswani, R.G.,Leblanc, Y.,Cote, A.,Nasveschuk, C.G.,Taylor, A.M.,Harmange, J.C.,Audia, J.E.,Pardo, E.,Joshi, S.,Sandy, P.,Mertz, J.A.,Sims, R.J.,Bergeron, L.,Bryant, B.M.,Bellon, S.,Poy, F.,Jayaram, H.,Sankaranarayanan, R.,Yellapantula, S.,Bangalore Srinivasamurthy, N.,Birudukota, S.,Albrecht, B.K. Discovery, Design, and Optimization of Isoxazole Azepine BET Inhibitors. ACS Med Chem Lett, 4:835-840, 2013 Cited by PubMed: 24900758DOI: 10.1021/ml4001485 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.21 Å) |
Structure validation
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