4LRG

Structure of BRD4 bromodomain 1 with a dimethyl thiophene isoxazole azepine carboxamide

4LRG の概要

• エントリーDOI: 10.2210/pdb4lrg/pdb
• 関連するPDBエントリー: 4LR6
• 分子名称: Bromodomain-containing protein 4, 2-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-[1,2]oxazolo[5,4-c]thieno[2,3-e]azepin-6-yl]acetamide (3 entities in total)
• 機能のキーワード: bet inhibitor, brd4 first bromodomain, transcription regulator-inhibitor complex, transcription regulator/inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: O60885
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15526.23

構造登録者

Ravichandran, S.,Jayaram, H.,Poy, F.,Gehling, V.,Hewitt, M.,Vaswani, R.,Leblanc, Y.,Cote, A.,Nasveschuk, C.,Taylor, A.,Harmange, J.-C.,Audia, J.,Pardo, E.,Joshi, S.,Sandy, P.,Mertz, J.,Sims, R.,Bergeron, L.,Bryant, B.,Yellapuntala, S.,Nandana, B.S.,Birudukota, S.,Albrecht, B.,Bellon, S. (登録日: 2013-07-19, 公開日: 2013-08-07, 最終更新日: 2024-02-28)

• 主引用文献: Gehling, V.S.,Hewitt, M.C.,Vaswani, R.G.,Leblanc, Y.,Cote, A.,Nasveschuk, C.G.,Taylor, A.M.,Harmange, J.C.,Audia, J.E.,Pardo, E.,Joshi, S.,Sandy, P.,Mertz, J.A.,Sims, R.J.,Bergeron, L.,Bryant, B.M.,Bellon, S.,Poy, F.,Jayaram, H.,Sankaranarayanan, R.,Yellapantula, S.,Bangalore Srinivasamurthy, N.,Birudukota, S.,Albrecht, B.K.; Discovery, Design, and Optimization of Isoxazole Azepine BET Inhibitors.; ACS Med Chem Lett, 4:835-840, 2013; PubMed: 24900758; DOI: 10.1021/ml4001485

実験手法

X-RAY DIFFRACTION (2.21 Å)