4LQG

X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with a phosphoramidate inhibitor CTT1056

4LQG の概要

• エントリーDOI: 10.2210/pdb4lqg/pdb
• 関連するBIRD辞書のPRD_ID: PRD_001140
• 分子名称: Glutamate carboxypeptidase 2, N-(4-fluorobenzoyl)-L-gamma-glutamyl-5-{[(S)-{[(1S)-1,3-dicarboxypropyl]amino}(hydroxy)phosphoryl]oxy}-L-norvaline, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total)
• 機能のキーワード: peptidase, hydrolase, metallopeptidase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell membrane ; Single-pass type II membrane protein . Isoform PSMA': Cytoplasm : Q04609
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 84164.10

構造登録者

Barinka, C.,Skultetyova, L. (登録日: 2013-07-18, 公開日: 2014-12-31, 最終更新日: 2020-07-29)

• 主引用文献: Dannoon, S.,Ganguly, T.,Cahaya, H.,Geruntho, J.J.,Galliher, M.S.,Beyer, S.K.,Choy, C.J.,Hopkins, M.R.,Regan, M.,Blecha, J.E.,Skultetyova, L.,Drake, C.R.,Jivan, S.,Barinka, C.,Jones, E.F.,Berkman, C.E.,VanBrocklin, H.F.; Structure-Activity Relationship of (18)F-Labeled Phosphoramidate Peptidomimetic Prostate-Specific Membrane Antigen (PSMA)-Targeted Inhibitor Analogues for PET Imaging of Prostate Cancer.; J.Med.Chem., 59:5684-5694, 2016; PubMed: 27228467; DOI: 10.1021/acs.jmedchem.5b01850

実験手法

X-RAY DIFFRACTION (1.77 Å)