4LP6

Crystal Structure of Human Carbonic Anhydrase II in complex with a quinoline oligoamide foldamer

Summary for 4LP6

• Entry DOI: 10.2210/pdb4lp6/pdb
• Descriptor: Carbonic anhydrase 2, 8-({[4-(3-aminopropoxy)-8-({[4-hydroxy-8-({[4-(2-methylpropoxy)-8-({[4-(3-{[(4-sulfamoylbenzoyl)amino]methyl}phenoxy)butyl]carbamoyl}amino)quinolin-2-yl]carbonyl}amino)quinolin-2-yl]carbonyl}amino)quinolin-2-yl]carbonyl}amino)-4-(carboxymethoxy)quinoline-2-carboxylic acid, ZINC ION, ... (4 entities in total)
• Functional Keywords: protein-foldamer complex, protein foldamer interactions, modified inhibitor, anchored foldamer, hcaii dimerisation, quinoline oligoamide foldamer, benzene sulfonamide modified inhibitor, lyase-lyase inhibitor complex, lyase/lyase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P00918
• Total number of polymer chains: 2
• Total formula weight: 62103.19

Authors

Buratto, J.,Granier, T.,Langlois D'estaintot, B.,Huc, I.,Gallois, B. (deposition date: 2013-07-15, release date: 2013-10-23, Last modification date: 2024-03-13)

• Primary citation: Buratto, J.,Colombo, C.,Stupfel, M.,Dawson, S.J.,Dolain, C.,Langlois d'Estaintot, B.,Fischer, L.,Granier, T.,Laguerre, M.,Gallois, B.,Huc, I.; Structure of a complex formed by a protein and a helical aromatic oligoamide foldamer at 2.1 angstrom resolution.; Angew.Chem.Int.Ed.Engl., 53:883-887, 2014; PubMed: 24288253; DOI: 10.1002/anie.201309160

Experimental method

X-RAY DIFFRACTION (2.15 Å)