4LP6
Crystal Structure of Human Carbonic Anhydrase II in complex with a quinoline oligoamide foldamer
Summary for 4LP6
Entry DOI | 10.2210/pdb4lp6/pdb |
Descriptor | Carbonic anhydrase 2, 8-({[4-(3-aminopropoxy)-8-({[4-hydroxy-8-({[4-(2-methylpropoxy)-8-({[4-(3-{[(4-sulfamoylbenzoyl)amino]methyl}phenoxy)butyl]carbamoyl}amino)quinolin-2-yl]carbonyl}amino)quinolin-2-yl]carbonyl}amino)quinolin-2-yl]carbonyl}amino)-4-(carboxymethoxy)quinoline-2-carboxylic acid, ZINC ION, ... (4 entities in total) |
Functional Keywords | protein-foldamer complex, protein foldamer interactions, modified inhibitor, anchored foldamer, hcaii dimerisation, quinoline oligoamide foldamer, benzene sulfonamide modified inhibitor, lyase-lyase inhibitor complex, lyase/lyase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P00918 |
Total number of polymer chains | 2 |
Total formula weight | 62103.19 |
Authors | Buratto, J.,Granier, T.,Langlois D'estaintot, B.,Huc, I.,Gallois, B. (deposition date: 2013-07-15, release date: 2013-10-23, Last modification date: 2024-03-13) |
Primary citation | Buratto, J.,Colombo, C.,Stupfel, M.,Dawson, S.J.,Dolain, C.,Langlois d'Estaintot, B.,Fischer, L.,Granier, T.,Laguerre, M.,Gallois, B.,Huc, I. Structure of a complex formed by a protein and a helical aromatic oligoamide foldamer at 2.1 angstrom resolution. Angew.Chem.Int.Ed.Engl., 53:883-887, 2014 Cited by PubMed: 24288253DOI: 10.1002/anie.201309160 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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