4LP6

Crystal Structure of Human Carbonic Anhydrase II in complex with a quinoline oligoamide foldamer

4LP6 の概要

• エントリーDOI: 10.2210/pdb4lp6/pdb
• 分子名称: Carbonic anhydrase 2, 8-({[4-(3-aminopropoxy)-8-({[4-hydroxy-8-({[4-(2-methylpropoxy)-8-({[4-(3-{[(4-sulfamoylbenzoyl)amino]methyl}phenoxy)butyl]carbamoyl}amino)quinolin-2-yl]carbonyl}amino)quinolin-2-yl]carbonyl}amino)quinolin-2-yl]carbonyl}amino)-4-(carboxymethoxy)quinoline-2-carboxylic acid, ZINC ION, ... (4 entities in total)
• 機能のキーワード: protein-foldamer complex, protein foldamer interactions, modified inhibitor, anchored foldamer, hcaii dimerisation, quinoline oligoamide foldamer, benzene sulfonamide modified inhibitor, lyase-lyase inhibitor complex, lyase/lyase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P00918
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 62103.19

構造登録者

Buratto, J.,Granier, T.,Langlois D'estaintot, B.,Huc, I.,Gallois, B. (登録日: 2013-07-15, 公開日: 2013-10-23, 最終更新日: 2024-03-13)

• 主引用文献: Buratto, J.,Colombo, C.,Stupfel, M.,Dawson, S.J.,Dolain, C.,Langlois d'Estaintot, B.,Fischer, L.,Granier, T.,Laguerre, M.,Gallois, B.,Huc, I.; Structure of a complex formed by a protein and a helical aromatic oligoamide foldamer at 2.1 angstrom resolution.; Angew.Chem.Int.Ed.Engl., 53:883-887, 2014; PubMed: 24288253; DOI: 10.1002/anie.201309160

実験手法

X-RAY DIFFRACTION (2.15 Å)