4LKU

Structure of the C-terminal domain of the E. coli mechanosensitive channel of large conductance

4LKU の概要

• エントリーDOI: 10.2210/pdb4lku/pdb
• 分子名称: Large-conductance mechanosensitive channel (2 entities in total)
• 機能のキーワード: pentamer, transport protein
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 16188.07

構造登録者

Walton, T.A.,Rees, D.C. (登録日: 2013-07-08, 公開日: 2013-10-02, 最終更新日: 2024-02-28)

主引用文献

Walton, T.A.,Rees, D.C.
Structure and stability of the C-terminal helical bundle of the E. coli mechanosensitive channel of large conductance.
Protein Sci., 22:1592-1601, 2013

PubMed Abstract: The crystal structure of the cytoplasmic domain (CTD) from the mechanosensitive channel of large conductance (MscL) in E. coli has been determined at 1.45 Å resolution. This domain forms a pentameric coiled coil similar to that observed in the structure of MscL from M. tuberculosis and also found in the cartilage oligomeric matrix protein (COMPcc). It contains canonical hydrophobic and atypical ionic interactions compared to previously characterized coiled coil structures. Thermodynamic analysis indicates that while the free EcMscL-CTD is less stable than other coiled coils, it is likely to remain folded in context of the full-length channel.

PubMed: 24038743
DOI: 10.1002/pro.2360

実験手法

X-RAY DIFFRACTION (1.45 Å)