4LKQ

Crystal structure of PDE10A2 with fragment ZT017

Summary for 4LKQ

Entry DOI	10.2210/pdb4lkq/pdb
Related	4LLJ 4LLL 4LLP 4LLX 4LM0 4LM1 4LM2 4LM3 4LM4
Descriptor	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, 4-amino-1,7-dihydro-6H-pyrazolo[3,4-d]pyrimidine-6-thione, NICKEL (II) ION, ... (4 entities in total)
Functional Keywords	fragment screening, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: Q9Y233
Total number of polymer chains	2
Total formula weight	79360.45
Authors	Sridhar, V.,Badger, J.,Logan, C.,Chie-Leon, B.,Nienaber, V. (deposition date: 2013-07-08, release date: 2014-02-26, Last modification date: 2023-09-20)
Primary citation	Recht, M.I.,Sridhar, V.,Badger, J.,Bounaud, P.Y.,Logan, C.,Chie-Leon, B.,Nienaber, V.,Torres, F.E. Identification and Optimization of PDE10A Inhibitors Using Fragment-Based Screening by Nanocalorimetry and X-ray Crystallography. J Biomol Screen, 19:497-507, 2014 Cited by PubMed: 24375910 DOI: 10.1177/1087057113516493 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.62 Å)

Structure validation