4LI5
EGFR-K IN COMPLEX WITH N-[3-[[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]-4-methoxy-phenyl] Prop-2-enamide
4LI5 の概要
エントリーDOI | 10.2210/pdb4li5/pdb |
分子名称 | Epidermal growth factor receptor, N-(3-{[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino}-4-methoxyphenyl)propanamide, SODIUM ION, ... (4 entities in total) |
機能のキーワード | egf receptor kinase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
由来する生物種 | Homo sapiens (human) |
細胞内の位置 | Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 37839.15 |
構造登録者 | Debreczeni, J.E.,Seiffert, G.B.,Kiefersauer, R.,Augustin, M.,Nagel, S.,Ward, R.,Anderton, M.,Ashton, S.,Bethel, P.,Box, M.,Butterworth, S.,Colclough, N.,Chroley, C.,Chuaqui, C.,Cross, D.,Eberlein, C.,Finlay, R.,Hill, G.,Grist, M.,Klinowska, T.,Lane, C.,Martin, S.,Orme, J.,Smith, P.,Wang, F.,Waring, M. (登録日: 2013-07-02, 公開日: 2013-08-28, 最終更新日: 2024-02-28) |
主引用文献 | Ward, R.A.,Anderton, M.J.,Ashton, S.,Bethel, P.A.,Box, M.,Butterworth, S.,Colclough, N.,Chorley, C.G.,Chuaqui, C.,Cross, D.A.,Dakin, L.A.,Debreczeni, J.E.,Eberlein, C.,Finlay, M.R.,Hill, G.B.,Grist, M.,Klinowska, T.C.,Lane, C.,Martin, S.,Orme, J.P.,Smith, P.,Wang, F.,Waring, M.J. Structure- and Reactivity-Based Development of Covalent Inhibitors of the Activating and Gatekeeper Mutant Forms of the Epidermal Growth Factor Receptor (EGFR). J.Med.Chem., 56:7025-7048, 2013 Cited by PubMed: 23930994DOI: 10.1021/jm400822z 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.64 Å) |
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