Loading
PDBj
メニューPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help

4LG6

Crystal structure of ANKRA2-CCDC8 complex

4LG6 の概要
エントリーDOI10.2210/pdb4lg6/pdb
分子名称Ankyrin repeat family A protein 2, Coiled-coil domain-containing protein 8, UNKNOWN ATOM OR ION, ... (4 entities in total)
機能のキーワードstructural genomics consortium, sgc, ankyrin repeat, structural protein
由来する生物種Homo sapiens (human)
詳細
細胞内の位置Cytoplasm, cytoskeleton : Q9H9E1
Cytoplasm : Q9H0W5
タンパク質・核酸の鎖数2
化学式量合計20861.77
構造登録者
Xu, C.,Bian, C.,Tempel, W.,Mackenzie, F.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Min, J.,Structural Genomics Consortium (SGC) (登録日: 2013-06-27, 公開日: 2013-09-25, 最終更新日: 2023-09-20)
主引用文献Nie, J.,Xu, C.,Jin, J.,Aka, J.A.,Tempel, W.,Nguyen, V.,You, L.,Weist, R.,Min, J.,Pawson, T.,Yang, X.J.
Ankyrin Repeats of ANKRA2 Recognize a PxLPxL Motif on the 3M Syndrome Protein CCDC8.
Structure, 23:700-712, 2015
Cited by
PubMed Abstract: Peptide motifs are often used for protein-protein interactions. We have recently demonstrated that ankyrin repeats of ANKRA2 and the paralogous bare lymphocyte syndrome transcription factor RFXANK recognize PxLPxL/I motifs shared by megalin, three histone deacetylases, and RFX5. We show here that that CCDC8 is a major partner of ANKRA2 but not RFXANK in cells. The CCDC8 gene is mutated in 3M syndrome, a short-stature disorder with additional facial and skeletal abnormalities. Two other genes mutated in this syndrome encode CUL7 and OBSL1. While CUL7 is a ubiquitin ligase and OBSL1 associates with the cytoskeleton, little is known about CCDC8. Binding and structural analyses reveal that the ankyrin repeats of ANKRA2 recognize a PxLPxL motif at the C-terminal region of CCDC8. The N-terminal part interacts with OBSL1 to form a CUL7 ligase complex. These results link ANKRA2 unexpectedly to 3M syndrome and suggest novel regulatory mechanisms for histone deacetylases and RFX7.
PubMed: 25752541
DOI: 10.1016/j.str.2015.02.001
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (1.8 Å)
構造検証レポート
Validation report summary of 4lg6
検証レポート(詳細版)ダウンロードをダウンロード

229183

件を2024-12-18に公開中

PDB statisticsPDBj update infoContact PDBjnumon