4LCX
The structure of hemagglutinin from avian-origin H7N9 influenza virus (A/Shanghai/1/2013)
4LCX の概要
エントリーDOI | 10.2210/pdb4lcx/pdb |
関連するPDBエントリー | 4KOL 4KOM 4KON |
分子名称 | Hemagglutinin HA1, Hemagglutinin HA2, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total) |
機能のキーワード | homotrimer, virus attachment and membrane fusion, viral protein |
由来する生物種 | Influenza A virus 詳細 |
タンパク質・核酸の鎖数 | 6 |
化学式量合計 | 163024.45 |
構造登録者 | |
主引用文献 | Shi, Y.,Zhang, W.,Wang, F.,Qi, J.,Wu, Y.,Song, H.,Gao, F.,Bi, Y.,Zhang, Y.,Fan, Z.,Qin, C.,Sun, H.,Liu, J.,Haywood, J.,Liu, W.,Gong, W.,Wang, D.,Shu, Y.,Wang, Y.,Yan, J.,Gao, G.F. Structures and receptor binding of hemagglutinins from human-infecting H7N9 influenza viruses. Science, 342:243-247, 2013 Cited by PubMed Abstract: An avian-origin human-infecting influenza (H7N9) virus was recently identified in China. We have evaluated the viral hemagglutinin (HA) receptor-binding properties of two human H7N9 isolates, A/Shanghai/1/2013 (SH-H7N9) (containing the avian-signature residue Gln(226)) and A/Anhui/1/2013 (AH-H7N9) (containing the mammalian-signature residue Leu(226)). We found that SH-H7N9 HA preferentially binds the avian receptor analog, whereas AH-H7N9 HA binds both avian and human receptor analogs. Furthermore, an AH-H7N9 mutant HA (Leu(226) → Gln) was found to exhibit dual receptor-binding property, indicating that other amino acid substitutions contribute to the receptor-binding switch. The structures of SH-H7N9 HA, AH-H7N9 HA, and its mutant in complex with either avian or human receptor analogs show how AH-H7N9 can bind human receptors while still retaining the avian receptor-binding property. PubMed: 24009358DOI: 10.1126/science.1242917 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (3.094 Å) |
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