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4LCX

The structure of hemagglutinin from avian-origin H7N9 influenza virus (A/Shanghai/1/2013)

4LCX の概要
エントリーDOI10.2210/pdb4lcx/pdb
関連するPDBエントリー4KOL 4KOM 4KON
分子名称Hemagglutinin HA1, Hemagglutinin HA2, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
機能のキーワードhomotrimer, virus attachment and membrane fusion, viral protein
由来する生物種Influenza A virus
詳細
タンパク質・核酸の鎖数6
化学式量合計163024.45
構造登録者
Shi, Y.,Zhang, W.,Wang, F.,Qi, J.,Song, H.,Wu, Y.,Gao, F.,Zhang, Y.,Fan, Z.,Gong, W.,Wang, D.,Shu, Y.,Wang, Y.,Yan, J.,Gao, G.F. (登録日: 2013-06-24, 公開日: 2013-11-06, 最終更新日: 2020-07-29)
主引用文献Shi, Y.,Zhang, W.,Wang, F.,Qi, J.,Wu, Y.,Song, H.,Gao, F.,Bi, Y.,Zhang, Y.,Fan, Z.,Qin, C.,Sun, H.,Liu, J.,Haywood, J.,Liu, W.,Gong, W.,Wang, D.,Shu, Y.,Wang, Y.,Yan, J.,Gao, G.F.
Structures and receptor binding of hemagglutinins from human-infecting H7N9 influenza viruses.
Science, 342:243-247, 2013
Cited by
PubMed Abstract: An avian-origin human-infecting influenza (H7N9) virus was recently identified in China. We have evaluated the viral hemagglutinin (HA) receptor-binding properties of two human H7N9 isolates, A/Shanghai/1/2013 (SH-H7N9) (containing the avian-signature residue Gln(226)) and A/Anhui/1/2013 (AH-H7N9) (containing the mammalian-signature residue Leu(226)). We found that SH-H7N9 HA preferentially binds the avian receptor analog, whereas AH-H7N9 HA binds both avian and human receptor analogs. Furthermore, an AH-H7N9 mutant HA (Leu(226) → Gln) was found to exhibit dual receptor-binding property, indicating that other amino acid substitutions contribute to the receptor-binding switch. The structures of SH-H7N9 HA, AH-H7N9 HA, and its mutant in complex with either avian or human receptor analogs show how AH-H7N9 can bind human receptors while still retaining the avian receptor-binding property.
PubMed: 24009358
DOI: 10.1126/science.1242917
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (3.094 Å)
構造検証レポート
Validation report summary of 4lcx
検証レポート(詳細版)ダウンロードをダウンロード

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件を2024-11-06に公開中

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