4LBR
Crystal structure of human AR complexed with NADP+ and {5-chloro-2-[(2,6-difluoro-4-iodobenzyl)carbamoyl]phenoxy}acetic acid
Summary for 4LBR
Entry DOI | 10.2210/pdb4lbr/pdb |
Related | 1US0 2IKI 4LAU 4LAZ 4LB3 4LB4 4LBS |
Descriptor | Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, {5-chloro-2-[(2,6-difluoro-4-iodobenzyl)carbamoyl]phenoxy}acetic acid, ... (4 entities in total) |
Functional Keywords | tim barrel, aldose reductase, oxidoreductase, diabetes, halogenated compound, cytosolic |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P15121 |
Total number of polymer chains | 1 |
Total formula weight | 37123.36 |
Authors | Cousido-Siah, A.,Mitschler, A.,Ruiz, F.X.,Fanfrlik, J.,Kolar, M.,Hobza, P.,Podjarny, A. (deposition date: 2013-06-21, release date: 2014-04-30, Last modification date: 2023-09-20) |
Primary citation | Fanfrlik, J.,Kolar, M.,Kamlar, M.,Hurny, D.,Ruiz, F.X.,Cousido-Siah, A.,Mitschler, A.,Rezac, J.,Munusamy, E.,Lepsik, M.,Matejicek, P.,Vesely, J.,Podjarny, A.,Hobza, P. Modulation of aldose reductase inhibition by halogen bond tuning. Acs Chem.Biol., 8:2484-2492, 2013 Cited by PubMed: 23988122DOI: 10.1021/cb400526n PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (0.8 Å) |
Structure validation
Download full validation report