4LBD
LIGAND-BINDING DOMAIN OF THE HUMAN RETINOIC ACID RECEPTOR GAMMA BOUND TO THE SYNTHETIC AGONIST BMS961
Summary for 4LBD
Entry DOI | 10.2210/pdb4lbd/pdb |
Descriptor | RETINOIC ACID RECEPTOR GAMMA, 3-FLUORO-4-[2-HYDROXY-2-(5,5,8,8-TETRAMETHYL-5,6,7,8,-TETRAHYDRO-NAPHTALEN-2-YL)-ACETYLAMINO]-BENZOIC ACID (3 entities in total) |
Functional Keywords | nuclear receptor, retinoic acid receptor, all-trans retinoic acid, ligand-binding domain, complex, holo form, transcription regulation, ligand-dependent, active conformation, structural proteomics in europe, spine, structural genomics |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 30592.51 |
Authors | Klaholz, B.P.,Renaud, J.-P.,Mitschler, A.,Moras, D.,Structural Proteomics in Europe (SPINE) (deposition date: 1998-02-04, release date: 1999-03-02, Last modification date: 2024-05-22) |
Primary citation | Klaholz, B.P.,Renaud, J.P.,Mitschler, A.,Zusi, C.,Chambon, P.,Gronemeyer, H.,Moras, D. Conformational adaptation of agonists to the human nuclear receptor RAR gamma. Nat.Struct.Biol., 5:199-202, 1998 Cited by PubMed: 9501913DOI: 10.1038/nsb0398-199 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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