4LB7
Crystal structure of human alpha-defensin 1 (HNP1) Y16A/I20A/L25A/F28A mutant.
Summary for 4LB7
Entry DOI | 10.2210/pdb4lb7/pdb |
Related | 3GNY 4LB1 4LBB 4LBF |
Descriptor | Neutrophil defensin 1 (2 entities in total) |
Functional Keywords | antimicrobial peptide, human alpha defensin 1, human neutrophil peptide 1, hnp1, antibiotic, antiviral defense, defensin, disulfide bond, fungicide, phosphoprotein, secreted, antimicrobial protein |
Biological source | Homo sapiens (human) |
Cellular location | Secreted: P59665 |
Total number of polymer chains | 4 |
Total formula weight | 12799.04 |
Authors | Tolbert, W.D.,Wu, X.,Pazgier, M. (deposition date: 2013-06-20, release date: 2013-11-27, Last modification date: 2023-09-20) |
Primary citation | Zhao, L.,Tolbert, W.D.,Ericksen, B.,Zhan, C.,Wu, X.,Yuan, W.,Li, X.,Pazgier, M.,Lu, W. Single, Double and Quadruple Alanine Substitutions at Oligomeric Interfaces Identify Hydrophobicity as the Key Determinant of Human Neutrophil Alpha Defensin HNP1 Function. Plos One, 8:e78937-e78937, 2013 Cited by PubMed: 24236072DOI: 10.1371/journal.pone.0078937 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.902 Å) |
Structure validation
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