4L96
Structure of the complex between the F360L PPARgamma mutant and the ligand LT175 (space group I222)
Summary for 4L96
Entry DOI | 10.2210/pdb4l96/pdb |
Related | 3B3K 4L98 |
Descriptor | Peroxisome proliferator-activated receptor gamma, (2S)-2-(biphenyl-4-yloxy)-3-phenylpropanoic acid (3 entities in total) |
Functional Keywords | transcription factor, rxralpha, transcription-transcription inhibitor complex, transcription/transcription inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 31694.84 |
Authors | Pochetti, G.,Montanari, R.,Capelli, D.,Chiaraluce, R.,Consalvi, V.,Pasquo, A.,Lori, C.,Laghezza, A.,Loiodice, F. (deposition date: 2013-06-18, release date: 2014-06-25, Last modification date: 2023-09-20) |
Primary citation | Lori, C.,Pasquo, A.,Montanari, R.,Capelli, D.,Consalvi, V.,Chiaraluce, R.,Cervoni, L.,Loiodice, F.,Laghezza, A.,Aschi, M.,Giorgi, A.,Pochetti, G. Structural basis of the transactivation deficiency of the human PPAR gamma F360L mutant associated with familial partial lipodystrophy. Acta Crystallogr.,Sect.D, 70:1965-1976, 2014 Cited by PubMed: 25004973DOI: 10.1107/S1399004714009638 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.38 Å) |
Structure validation
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