4L6Q
ROCK2 in complex with benzoxaborole
Summary for 4L6Q
Entry DOI | 10.2210/pdb4l6q/pdb |
Descriptor | Rho-associated protein kinase 2, 6-[4-(aminomethyl)-2-fluorophenoxy]-2,1-benzoxaborol-1(3H)-ol (3 entities in total) |
Functional Keywords | transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: O75116 |
Total number of polymer chains | 2 |
Total formula weight | 92346.38 |
Authors | Rock, F.,Jarnagin, K. (deposition date: 2013-06-12, release date: 2013-10-02, Last modification date: 2024-02-28) |
Primary citation | Akama, T.,Dong, C.,Virtucio, C.,Sullivan, D.,Zhou, Y.,Zhang, Y.K.,Rock, F.,Freund, Y.,Liu, L.,Bu, W.,Wu, A.,Fan, X.Q.,Jarnagin, K. Linking phenotype to kinase: identification of a novel benzoxaborole hinge-binding motif for kinase inhibition and development of high-potency rho kinase inhibitors. J.Pharmacol.Exp.Ther., 347:615-625, 2013 Cited by PubMed: 24049062DOI: 10.1124/jpet.113.207662 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.79 Å) |
Structure validation
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