4L6Q

ROCK2 in complex with benzoxaborole

4L6Q の概要

• エントリーDOI: 10.2210/pdb4l6q/pdb
• 分子名称: Rho-associated protein kinase 2, 6-[4-(aminomethyl)-2-fluorophenoxy]-2,1-benzoxaborol-1(3H)-ol (3 entities in total)
• 機能のキーワード: transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: O75116
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 92346.38

構造登録者

Rock, F.,Jarnagin, K. (登録日: 2013-06-12, 公開日: 2013-10-02, 最終更新日: 2024-02-28)

• 主引用文献: Akama, T.,Dong, C.,Virtucio, C.,Sullivan, D.,Zhou, Y.,Zhang, Y.K.,Rock, F.,Freund, Y.,Liu, L.,Bu, W.,Wu, A.,Fan, X.Q.,Jarnagin, K.; Linking phenotype to kinase: identification of a novel benzoxaborole hinge-binding motif for kinase inhibition and development of high-potency rho kinase inhibitors.; J.Pharmacol.Exp.Ther., 347:615-625, 2013; PubMed: 24049062; DOI: 10.1124/jpet.113.207662

実験手法

X-RAY DIFFRACTION (2.79 Å)