4L59

Crystal structure of the 3-MBT repeat domain of L3MBTL3 and UNC2533 complex

4L59 の概要

• エントリーDOI: 10.2210/pdb4l59/pdb
• 分子名称: Lethal(3)malignant brain tumor-like protein 3, 4-(pyrrolidin-1-yl)-1-{4-[2-(pyrrolidin-1-yl)ethyl]phenyl}piperidine, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: 3-mbt repeat domain, l3mbtl3, unc2533, structural genomics, structural genomics consortium, sgc, transcription
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus : Q96JM7
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37073.20

構造登録者

Zhong, N.,Dong, A.,Ravichandran, M.,Camerino, M.A.,Dickson, B.M.,James, L.I.,Baughman, B.M.,Norris, J.L.,Kireev, D.B.,Janzen, W.P.,Graslund, S.,Frye, S.V.,Bountra, C.,Edwards, A.M.,Arrowsmith, C.H.,Brown, P.J.,Structural Genomics Consortium (SGC) (登録日: 2013-06-10, 公開日: 2013-07-10, 最終更新日: 2023-09-20)

• 主引用文献: Camerino, M.A.,Zhong, N.,Dong, A.,Dickson, B.M.,James, L.I.,Baughman, B.M.,Norris, J.L.,Kireev, D.B.,Janzen, W.P.,Arrowsmith, C.H.,Frye, S.V.; The structure-activity relationships of L3MBTL3 inhibitors: flexibility of the dimer interface.; Medchemcomm, 4:1501-1507, 2013; PubMed: 24466405; DOI: 10.1039/C3MD00197K

実験手法

X-RAY DIFFRACTION (2.29 Å)