4L4L

Structural Analysis of a Phosphoribosylated Inhibitor in Complex with Human Nicotinamide Phosphoribosyltransferase

4L4L の概要

• エントリーDOI: 10.2210/pdb4l4l/pdb
• 関連するPDBエントリー: 4L4M
• 分子名称: Nicotinamide phosphoribosyltransferase, 6-({4-[(3,5-difluorophenyl)sulfonyl]benzyl}carbamoyl)-1-(5-O-phosphono-beta-D-ribofuranosyl)imidazo[1,2-a]pyridin-1-ium, PHOSPHATE ION, ... (5 entities in total)
• 機能のキーワード: transferase, inhibitor prpp adduct, active site, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: P43490
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 115731.89

構造登録者

Oh, A.,Ho, Y.,Zak, M.,Liu, Y.,Yuen, P.,Zheng, X.,Dragovich, S.P.,Wang, W. (登録日: 2013-06-08, 公開日: 2014-06-11, 最終更新日: 2024-02-28)

• 主引用文献: Oh, A.,Ho, Y.C.,Zak, M.,Liu, Y.,Chen, X.,Yuen, P.W.,Zheng, X.,Liu, Y.,Dragovich, P.S.,Wang, W.; Structural and biochemical analyses of the catalysis and potency impact of inhibitor phosphoribosylation by human nicotinamide phosphoribosyltransferase.; Chembiochem, 15:1121-1130, 2014; PubMed: 24797455; DOI: 10.1002/cbic.201402023

実験手法

X-RAY DIFFRACTION (2.122 Å)