4L27
Crystal structure of delta1-39 and delta516-525 human cystathionine beta-synthase D444N mutant containing C-terminal 6xHis tag
Summary for 4L27
Entry DOI | 10.2210/pdb4l27/pdb |
Related | 1JBQ 4L0D 4L28 4L3V |
Descriptor | Cystathionine beta-synthase, PYRIDOXAL-5'-PHOSPHATE, PROTOPORPHYRIN IX CONTAINING FE (3 entities in total) |
Functional Keywords | cbs domain, homocyteine, cysteine biosynthesis, heme, pyridoxal 5'-phosphate, s-adenosylmethionine, transsulfuration pathway, lyase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P35520 |
Total number of polymer chains | 4 |
Total formula weight | 245507.27 |
Authors | Ereno, J.,Majtan, T.,Oyenarte, I.,Kraus, J.P.,Martinez, L.A. (deposition date: 2013-06-04, release date: 2013-09-18, Last modification date: 2023-09-20) |
Primary citation | Ereno-Orbea, J.,Majtan, T.,Oyenarte, I.,Kraus, J.P.,Martinez-Cruz, L.A. Structural basis of regulation and oligomerization of human cystathionine beta-synthase, the central enzyme of transsulfuration. Proc.Natl.Acad.Sci.USA, 110:E3790-E3799, 2013 Cited by PubMed: 24043838DOI: 10.1073/pnas.1313683110 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.391 Å) |
Structure validation
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