4L1S

Covalent modification of transthyretin K15 by yielding the fluorescent conjugate (E)-3-(dimethylamino)-5-(4-hydroxy-3,5-dimethylstyryl)benzamide

4L1S の概要

• エントリーDOI: 10.2210/pdb4l1s/pdb
• 関連するPDBエントリー: 4FI6 4L1T
• 分子名称: Transthyretin, S-(4-fluorophenyl) 3-(dimethylamino)-5-[(E)-2-(4-hydroxy-3,5-dimethylphenyl)ethenyl]benzenecarbothioate (3 entities in total)
• 機能のキーワード: hormone transport protein, thyroxine, retinol, transport protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted: P02766
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 28397.77

構造登録者

Connelly, S.,Wilson, I.A. (登録日: 2013-06-03, 公開日: 2013-10-02, 最終更新日: 2023-09-20)

• 主引用文献: Baranczak, A.,Connelly, S.,Liu, Y.,Choi, S.,Grimster, N.P.,Powers, E.T.,Wilson, I.A.,Kelly, J.W.; Fluorogenic small molecules requiring reaction with a specific protein to create a fluorescent conjugate for biological imaging-what we know and what we need to learn.; Biopolymers, 101:484-495, 2014; PubMed: 24105107; DOI: 10.1002/bip.22407

実験手法

X-RAY DIFFRACTION (1.5 Å)