4L19
Matrix metalloproteinase-13 complexed with selective inhibitor compound Q1
Summary for 4L19
Entry DOI | 10.2210/pdb4l19/pdb |
Descriptor | Collagenase 3, ZINC ION, CALCIUM ION, ... (7 entities in total) |
Functional Keywords | metalloprotease, hydrolase, mmp-13, collagenase, exosite inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Secreted, extracellular space, extracellular matrix : P45452 |
Total number of polymer chains | 2 |
Total formula weight | 40281.63 |
Authors | Minond, D.,Spicer, T.P.,Jiang, J.,Taylor, A.B.,Hart, P.J.,Roush, W.R.,Fields, G.B.,Hodder, P.S. (deposition date: 2013-06-02, release date: 2014-12-10, Last modification date: 2023-09-20) |
Primary citation | Spicer, T.P.,Jiang, J.,Taylor, A.B.,Choi, J.Y.,Hart, P.J.,Roush, W.R.,Fields, G.B.,Hodder, P.S.,Minond, D. Characterization of selective exosite-binding inhibitors of matrix metalloproteinase 13 that prevent articular cartilage degradation in vitro. J.Med.Chem., 57:9598-9611, 2014 Cited by PubMed: 25330343DOI: 10.1021/jm501284e PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.66 Å) |
Structure validation
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