4L19

Matrix metalloproteinase-13 complexed with selective inhibitor compound Q1

4L19 の概要

• エントリーDOI: 10.2210/pdb4l19/pdb
• 分子名称: Collagenase 3, ZINC ION, CALCIUM ION, ... (7 entities in total)
• 機能のキーワード: metalloprotease, hydrolase, mmp-13, collagenase, exosite inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted, extracellular space, extracellular matrix : P45452
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 40281.63

構造登録者

Minond, D.,Spicer, T.P.,Jiang, J.,Taylor, A.B.,Hart, P.J.,Roush, W.R.,Fields, G.B.,Hodder, P.S. (登録日: 2013-06-02, 公開日: 2014-12-10, 最終更新日: 2023-09-20)

• 主引用文献: Spicer, T.P.,Jiang, J.,Taylor, A.B.,Choi, J.Y.,Hart, P.J.,Roush, W.R.,Fields, G.B.,Hodder, P.S.,Minond, D.; Characterization of selective exosite-binding inhibitors of matrix metalloproteinase 13 that prevent articular cartilage degradation in vitro.; J.Med.Chem., 57:9598-9611, 2014; PubMed: 25330343; DOI: 10.1021/jm501284e

実験手法

X-RAY DIFFRACTION (1.66 Å)