4KWI

The crystal structure of angucycline C-6 ketoreductase LanV with bound NADP and 11-deoxy-6-oxylandomycinone

Summary for 4KWI

• Entry DOI: 10.2210/pdb4kwi/pdb
• Related: 4KWH
• Descriptor: Reductase homolog, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 1,8-dihydroxy-3-methyltetraphene-6,7,12(5H)-trione, ... (5 entities in total)
• Functional Keywords: rossmann fold, ketoreductase, nadph binding, oxidoreductase-antibiotic complex, oxidoreductase/antibiotic
• Biological source: Streptomyces cyanogenus
• Total number of polymer chains: 2
• Total formula weight: 57235.67

Authors

Paananen, P.,Patrikainen, P.,Mantsala, P.,Niemi, J.,Niiranen, L.,Metsa-Ketela, M. (deposition date: 2013-05-24, release date: 2013-07-31, Last modification date: 2023-09-20)

• Primary citation: Paananen, P.,Patrikainen, P.,Kallio, P.,Mantsala, P.,Niemi, J.,Niiranen, L.,Metsa-Ketela, M.; Structural and functional analysis of angucycline C-6 ketoreductase LanV involved in landomycin biosynthesis.; Biochemistry, 52:5304-5314, 2013; PubMed: 23848284; DOI: 10.1021/bi400712q

Experimental method

X-RAY DIFFRACTION (2 Å)