4KUZ

Crystal structure of anti-emmprin antibody 4A5 Fab in trigonal form

4KUZ の概要

• エントリーDOI: 10.2210/pdb4kuz/pdb
• 分子名称: antibody 4A5 light chain, antibody 4A5 heavy chain, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: immunoglobulin fold, immune system
• 由来する生物種: Mus musculus, Homo sapiens (mouse, human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 49079.46

構造登録者

Teplyakov, A.,Obmolova, G.,Gilliland, G.L. (登録日: 2013-05-22, 公開日: 2014-03-26, 最終更新日: 2024-11-20)

主引用文献

Teplyakov, A.,Obmolova, G.,Malia, T.J.,Luo, J.,Gilliland, G.L.
Structural evidence for a constrained conformation of short CDR-L3 in antibodies.
Proteins, 82:1679-1683, 2014

PubMed Abstract: Three Fab structures used as targets in the Antibody Modeling Assessment presented a challenge for modeling CDR-L3 due to deviations from the most typical canonical structure. In all three antibodies CDR-L3 has eight residues, which is one residue shorter than usual, and has a conformation that is rarely observed in crystal structures. We analyzed the sequence and structural determinants of this conformation and found that the "short" CDR-L3 is remarkably rigid and retains the conformation in the interactions with antigens and neighboring CDRs.

PubMed: 24470236
DOI: 10.1002/prot.24522

実験手法

X-RAY DIFFRACTION (2.7 Å)