4KTD

Fab fragment of HIV vaccine-elicited CD4bs-directed antibody, GE136, from non-human primate

Summary for 4KTD

Related4KTE
DescriptorGE136 Heavy Chain Fab, GE136 Light Chain Fab, SULFATE ION, ... (5 entities in total)
Functional Keywordsantibody affinity, antibody specificity, vaccine elicited antibodies, fab fragment, aids vaccines, immune system
Biological sourceMacaca mulatta (rhesus macaque)
Total number of polymer chains2
Total molecular weight48477.89
Authors
Poulsen, C.,Tran, K.,Standfield, R.,Wyatt, R.T. (deposition date: 2013-05-20, release date: 2014-02-05, Last modification date: 2017-11-15)
Primary citation
Tran, K.,Poulsen, C.,Guenaga, J.,de Val Alda, N.,Wilson, R.,Sundling, C.,Li, Y.,Stanfield, R.L.,Wilson, I.A.,Ward, A.B.,Karlsson Hedestam, G.B.,Wyatt, R.T.
Vaccine-elicited primate antibodies use a distinct approach to the HIV-1 primary receptor binding site informing vaccine redesign.
Proc.Natl.Acad.Sci.USA, 111:E738-E747, 2014
PubMed: 24550318 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.1319512111
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.244200.3%0.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution