4KS8

PAK6 kinase domain in complex with sunitinib

Summary for 4KS8

• Entry DOI: 10.2210/pdb4ks8/pdb
• Related: 4KS7
• Descriptor: Serine/threonine-protein kinase PAK 6, N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carbo xamide (3 entities in total)
• Functional Keywords: protein kinase, phosphotransfer, phosphorylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: Q9NQU5
• Total number of polymer chains: 1
• Total formula weight: 33700.03

Authors

Gao, J.,Boggon, T.J. (deposition date: 2013-05-17, release date: 2013-09-11, Last modification date: 2023-09-20)

• Primary citation: Gao, J.,Ha, B.H.,Lou, H.J.,Morse, E.M.,Zhang, R.,Calderwood, D.A.,Turk, B.E.,Boggon, T.J.; Substrate and Inhibitor Specificity of the Type II p21-Activated Kinase, PAK6.; Plos One, 8:e77818-e77818, 2013; PubMed: 24204982; DOI: 10.1371/journal.pone.0077818

Experimental method

X-RAY DIFFRACTION (1.95 Å)