4KQJ

Crystal structure of CobT S80Y/Q88M/L175M complexed with p-cresol and NaMN

Summary for 4KQJ

• Entry DOI: 10.2210/pdb4kqj/pdb
• Related: 1JHU 1JHV 4KQF 4KQG 4KQH 4KQI
• Descriptor: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase, NICOTINATE MONONUCLEOTIDE, P-CRESOL, ... (5 entities in total)
• Functional Keywords: transferase
• Biological source: Salmonella enterica subsp. enterica serovar Typhimurium
• Total number of polymer chains: 1
• Total formula weight: 37282.17

Authors

Chan, C.H.,Newmister, S.A.,Taylor, K.C.,Claas, K.R.,Rayment, I.,Escalante-Semerena, J.C. (deposition date: 2013-05-15, release date: 2014-03-12, Last modification date: 2024-10-16)

Primary citation

Chan, C.H.,Newmister, S.A.,Talyor, K.,Claas, K.R.,Rayment, I.,Escalante-Semerena, J.C.
Dissecting cobamide diversity through structural and functional analyses of the base-activating CobT enzyme of Salmonella enterica.
Biochim.Biophys.Acta, 1840:464-475, 2014

PubMed Abstract: Cobamide diversity arises from the nature of the nucleotide base. Nicotinate mononucleotide (NaMN):base phosphoribosyltransferases (CobT) synthesize α-linked riboside monophosphates from diverse nucleotide base substrates (e.g., benzimidazoles, purines, phenolics) that are incorporated into cobamides.

PubMed: 24121107
DOI: 10.1016/j.bbagen.2013.09.038

Experimental method

X-RAY DIFFRACTION (1.95 Å)