4KQ6

Product complex of lumazine synthase from candida glabrata

「4GEF」から置き換えられました

4KQ6 の概要

• エントリーDOI: 10.2210/pdb4kq6/pdb
• 分子名称: 6,7-dimethyl-8-ribityllumazine synthase, SULFATE ION, 1-deoxy-1-(6,7-dimethyl-2,4-dioxo-3,4-dihydropteridin-8(2H)-yl)-D-ribitol, ... (5 entities in total)
• 機能のキーワード: lumazine synthase, riboflavin biosynthesis, transferase
• 由来する生物種: Candida glabrata (Yeast)
• タンパク質・核酸の鎖数: 10
• 化学式量合計: 199162.81

構造登録者

Shankar, M.,Wilbanks, S.M.,Nakatani, Y.,Monk, B.C.,Tyndall, J.D.A. (登録日: 2013-05-14, 公開日: 2013-05-29, 最終更新日: 2023-09-20)

主引用文献

Shankar, M.,Wilbanks, S.M.,Nakatani, Y.,Monk, B.C.,Tyndall, J.D.
Catalysis product captured in lumazine synthase from the fungal pathogen Candida glabrata.
Acta Crystallogr.,Sect.D, 69:1580-1586, 2013

PubMed Abstract: Candida glabrata has emerged as an important fungal pathogen with intrinsic resistance to azole drugs. The limited efficacy of and resistance to existing antifungals is driving the need to identify new drug targets. The enzyme 6,7-dimethyl-8-(D-ribityl)lumazine synthase is part of the riboflavin-biosynthesis pathway essential to fungi and bacteria and is a potential drug target for the development of broad-spectrum antifungal drugs. The X-ray crystal structure of recombinant lumazine synthase from C. glabrata was obtained at 2.24 Å resolution and revealed a dimer of homopentamers, with one in five subunits containing a product molecule from the catalytic reaction.

PubMed: 23897480
DOI: 10.1107/S0907444913010949

実験手法

X-RAY DIFFRACTION (2.24 Å)