4KPC

Crystal structure of the nucleoside diphosphate kinase b from Leishmania braziliensis

4KPC の概要

• エントリーDOI: 10.2210/pdb4kpc/pdb
• 分子名称: Nucleoside diphosphate kinase b, PHOSPHATE ION (3 entities in total)
• 機能のキーワード: ndpk superfamily, transferase
• 由来する生物種: Leishmania braziliensis
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 37952.68

構造登録者

Vieira, P.S.,Giuseppe, P.O.,Santos, C.R.,Cunha, E.M.F.,de Oliveira, A.H.C.,Murakami, M.T. (登録日: 2013-05-13, 公開日: 2014-07-09, 最終更新日: 2024-02-28)

主引用文献

Vieira, P.S.,de Giuseppe, P.O.,Murakami, M.T.,de Oliveira, A.H.
Crystal structure and biophysical characterization of the nucleoside diphosphate kinase from Leishmania braziliensis.
Bmc Struct.Biol., 15:2-2, 2015

PubMed Abstract: Nucleoside diphosphate kinase (NDK) is a housekeeping enzyme that plays key roles in nucleotide recycling and homeostasis in trypanosomatids. It is also secreted by the intracellular parasite Leishmania to modulate the host response. These functions make NDK an attractive target for drug design and for studies aiming at a better understanding of the mechanisms mediating host-pathogen interactions.

PubMed: 25643978
DOI: 10.1186/s12900-015-0030-8

実験手法

X-RAY DIFFRACTION (2.7 Å)