4KP6
Crystal structure of human phosphodiesterase 4B (PDE4B) in complex with a [1,3,5]triazine derivative
Summary for 4KP6
Entry DOI | 10.2210/pdb4kp6/pdb |
Descriptor | cAMP-specific 3',5'-cyclic phosphodiesterase 4B, 2-ethyl-2-{[4-(methylamino)-6-(1H-1,2,4-triazol-1-yl)-1,3,5-triazin-2-yl]amino}butanenitrile, MAGNESIUM ION, ... (6 entities in total) |
Functional Keywords | pde4 inhibitor, phosphodiesterase, triazine, neutrophilia, copd, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 40590.50 |
Authors | Gewald, R.,Grunwald, C.,Egerland, U. (deposition date: 2013-05-13, release date: 2013-07-10, Last modification date: 2024-02-28) |
Primary citation | Gewald, R.,Grunwald, C.,Egerland, U. Discovery of triazines as potent, selective and orally active PDE4 inhibitors. Bioorg.Med.Chem.Lett., 23:4308-4314, 2013 Cited by PubMed: 23806553DOI: 10.1016/j.bmcl.2013.05.099 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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