4KP6

Crystal structure of human phosphodiesterase 4B (PDE4B) in complex with a [1,3,5]triazine derivative

Summary for 4KP6

Entry DOI	10.2210/pdb4kp6/pdb
Descriptor	cAMP-specific 3',5'-cyclic phosphodiesterase 4B, 2-ethyl-2-{[4-(methylamino)-6-(1H-1,2,4-triazol-1-yl)-1,3,5-triazin-2-yl]amino}butanenitrile, MAGNESIUM ION, ... (6 entities in total)
Functional Keywords	pde4 inhibitor, phosphodiesterase, triazine, neutrophilia, copd, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	40590.50
Authors	Gewald, R.,Grunwald, C.,Egerland, U. (deposition date: 2013-05-13, release date: 2013-07-10, Last modification date: 2024-02-28)
Primary citation	Gewald, R.,Grunwald, C.,Egerland, U. Discovery of triazines as potent, selective and orally active PDE4 inhibitors. Bioorg.Med.Chem.Lett., 23:4308-4314, 2013 Cited by PubMed: 23806553 DOI: 10.1016/j.bmcl.2013.05.099 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation