4KO0

CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH an anilinylpyrimidine derivative (JLJ-135)

4KO0 の概要

• エントリーDOI: 10.2210/pdb4ko0/pdb
• 関連するPDBエントリー: 1S9E 2ZE2 3BGR 3V81 4G1Q 4KKO
• 分子名称: HIV-1 reverse transcriptase, p66 subunit, HIV-1 reverse transcriptase, p51 subunit, 4-[(4-methoxypyrimidin-2-yl)amino]-2-[(3-methylbut-2-en-1-yl)oxy]benzonitrile, ... (6 entities in total)
• 機能のキーワード: p51/p66, hetero dimer, nnrti, nonnucleoside inhibitor, aids, hiv, dna recombination, rna-directed dna polymerase, dna polymerase, endonuclease, hydrolase, multifunctional enzyme, transferase, hydrolase-inhibitor complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Human immunodeficiency virus type 1 (HIV-1); 詳細
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366 P03366
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 114655.34

構造登録者

Das, K.,Bauman, J.D.,Arnold, E. (登録日: 2013-05-10, 公開日: 2013-08-14, 最終更新日: 2023-09-20)

• 主引用文献: Bollini, M.,Frey, K.M.,Cisneros, J.A.,Spasov, K.A.,Das, K.,Bauman, J.D.,Arnold, E.,Anderson, K.S.,Jorgensen, W.L.; Extension into the entrance channel of HIV-1 reverse transcriptase-Crystallography and enhanced solubility.; Bioorg.Med.Chem.Lett., 23:5209-5212, 2013; PubMed: 23899617; DOI: 10.1016/j.bmcl.2013.06.093

実験手法

X-RAY DIFFRACTION (1.95 Å)