4KML

Probing the N-terminal beta-sheet conversion in the crystal structure of the full-length human prion protein bound to a Nanobody

Summary for 4KML

• Entry DOI: 10.2210/pdb4kml/pdb
• Related: 4N9O
• Descriptor: Major prion protein, Nanobody (3 entities in total)
• Functional Keywords: prion-like fold, antibody, nanobody, membrane protein-protein binding complex, membrane protein/protein binding
• Biological source: Homo sapiens (human); More
• Cellular location: Cell membrane; Lipid-anchor, GPI-anchor . Isoform 2: Cytoplasm : P04156
• Total number of polymer chains: 2
• Total formula weight: 40478.66

Authors

Abskharon, R.N.N.,Giachin, G.,Wohlkonig, A.,Soror, S.H.,Pardon, E.,Legname, G.,Steyaert, J. (deposition date: 2013-05-08, release date: 2014-02-19, Last modification date: 2023-09-20)

• Primary citation: Abskharon, R.N.,Giachin, G.,Wohlkonig, A.,Soror, S.H.,Pardon, E.,Legname, G.,Steyaert, J.; Probing the N-Terminal beta-Sheet Conversion in the Crystal Structure of the Human Prion Protein Bound to a Nanobody.; J.Am.Chem.Soc., 136:937-944, 2014; PubMed: 24400836; DOI: 10.1021/ja407527p

Experimental method

X-RAY DIFFRACTION (1.5 Å)