4KIT
Crystal structure of human Brr2 in complex with the Prp8 Jab1/MPN domain
Summary for 4KIT
Entry DOI | 10.2210/pdb4kit/pdb |
Descriptor | U5 small nuclear ribonucleoprotein 200 kDa helicase, Pre-mRNA-processing-splicing factor 8, ADENOSINE-5'-DIPHOSPHATE, ... (4 entities in total) |
Functional Keywords | reca domain, winged helix domain, sec63 unit, jab1/mpn domain, pre-mrna splicing, atp binding, rna binding, ubiquitin binding, rna binding protein |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: O75643 Nucleus speckle (By similarity): Q6P2Q9 |
Total number of polymer chains | 2 |
Total formula weight | 231525.49 |
Authors | Wahl, M.C.,Wandersleben, T.,Santos, K.F. (deposition date: 2013-05-02, release date: 2013-06-05, Last modification date: 2023-09-20) |
Primary citation | Mozaffari-Jovin, S.,Wandersleben, T.,Santos, K.F.,Will, C.L.,Luhrmann, R.,Wahl, M.C. Inhibition of RNA helicase Brr2 by the C-terminal tail of the spliceosomal protein Prp8. Science, 341:80-84, 2013 Cited by PubMed: 23704370DOI: 10.1126/science.1237515 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.598 Å) |
Structure validation
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