4KGL

Crystal structure of human alpha-L-iduronidase complex with [2R,3R,4R,5S]-2-carboxy-3,4,5-trihydroxy-piperidine

4KGL の概要

• エントリーDOI: 10.2210/pdb4kgl/pdb
• 関連するPDBエントリー: 4JXO 4JXP 4KGJ 4KH2
• 分子名称: Alpha-L-iduronidase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• 機能のキーワード: glycoside hydrolase family 39, tim barrel, beta sandwich, fibronectin iii domain, glycosaminoglycans, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Lysosome: P35475
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 144832.93

構造登録者

Bie, H.,Yin, J.,He, X.,Kermode, A.R.,Goddard-Borger, E.D.,Withers, S.G.,James, M.N.G. (登録日: 2013-04-29, 公開日: 2013-09-18, 最終更新日: 2023-09-20)

• 主引用文献: Bie, H.,Yin, J.,He, X.,Kermode, A.R.,Goddard-Borger, E.D.,Withers, S.G.,James, M.N.; Insights into mucopolysaccharidosis I from the structure and action of alpha-L-iduronidase.; Nat.Chem.Biol., 9:739-745, 2013; PubMed: 24036510; DOI: 10.1038/nchembio.1357

実験手法

X-RAY DIFFRACTION (2.701 Å)