4KFQ

Crystal structure of the NMDA receptor GluN1 ligand binding domain in complex with 1-thioxo-1,2-dihydro-[1,2,4]triazolo[4,3-a]quinoxalin-4(5H)-one

Summary for 4KFQ

• Entry DOI: 10.2210/pdb4kfq/pdb
• Related: 1PB7 1PB8 1PB9 1PBQ
• Descriptor: Glutamate receptor ionotropic, NMDA 1, 1-sulfanyl[1,2,4]triazolo[4,3-a]quinoxalin-4(5H)-one, GLYCEROL, ... (5 entities in total)
• Functional Keywords: membrane protein, ligand binding domain, ionotropic glutamate receptor
• Biological source: Rattus norvegicus (brown rat,rat,rats); More
• Cellular location: Cell membrane ; Multi-pass membrane protein : P35439
• Total number of polymer chains: 2
• Total formula weight: 69542.73

Authors

Steffensen, T.B.,Tabrizi, F.M.,Gajhede, M.,Kastrup, J.S. (deposition date: 2013-04-27, release date: 2013-10-09, Last modification date: 2023-09-20)

• Primary citation: Kvist, T.,Steffensen, T.B.,Greenwood, J.R.,Mehrzad Tabrizi, F.,Hansen, K.B.,Gajhede, M.,Pickering, D.S.,Traynelis, S.F.,Kastrup, J.S.,Brauner-Osborne, H.; Crystal structure and pharmacological characterization of a novel N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site.; J.Biol.Chem., 288:33124-33135, 2013; PubMed: 24072709; DOI: 10.1074/jbc.M113.480210

Experimental method

X-RAY DIFFRACTION (2.2 Å)