4KD1

CDK2 in complex with Dinaciclib

4KD1 の概要

• エントリーDOI: 10.2210/pdb4kd1/pdb
• 分子名称: Cyclin-dependent kinase 2, 1,2-ETHANEDIOL, 3-[({3-ethyl-5-[(2S)-2-(2-hydroxyethyl)piperidin-1-yl]pyrazolo[1,5-a]pyrimidin-7-yl}amino)methyl]-1-hydroxypyridinium, ... (4 entities in total)
• 機能のキーワード: protein kinase, dinaciclib, transferase-transferase, cell cycle-inhibitor complex, cell cycle/inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome: P24941
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34436.05

構造登録者

Martin, M.P.,Schonbrunn, E. (登録日: 2013-04-24, 公開日: 2013-09-18, 最終更新日: 2023-09-20)

• 主引用文献: Martin, M.P.,Olesen, S.H.,Georg, G.I.,Schonbrunn, E.; Cyclin-dependent kinase inhibitor dinaciclib interacts with the acetyl-lysine recognition site of bromodomains.; Acs Chem.Biol., 8:2360-2365, 2013; PubMed: 24007471; DOI: 10.1021/cb4003283

実験手法

X-RAY DIFFRACTION (1.7 Å)