4KAP
The Binding of Benzoarylsulfonamide Ligands to Human Carbonic Anhydrase is Insensitive to Formal Fluorination of the Ligand
Summary for 4KAP
Entry DOI | 10.2210/pdb4kap/pdb |
Descriptor | Carbonic anhydrase 2, ZINC ION, 4,5,6,7-tetrafluoro-1,3-benzothiazole-2-sulfonamide, ... (4 entities in total) |
Functional Keywords | alpha beta, lyase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P00918 |
Total number of polymer chains | 1 |
Total formula weight | 29331.31 |
Authors | Lange, H.,Lockett, M.R.,Breiten, B.,Heroux, A.,Sherman, W.,Rappoport, D.,Yau, P.O.,Snyder, P.W.,Whitesides, G.M. (deposition date: 2013-04-22, release date: 2013-07-10, Last modification date: 2024-02-28) |
Primary citation | Lockett, M.R.,Lange, H.,Breiten, B.,Heroux, A.,Sherman, W.,Rappoport, D.,Yau, P.O.,Snyder, P.W.,Whitesides, G.M. The Binding of Benzoarylsulfonamide Ligands to Human Carbonic Anhydrase is Insensitive to Formal Fluorination of the Ligand. Angew.Chem.Int.Ed.Engl., 52:7714-7717, 2013 Cited by PubMed: 23788494DOI: 10.1002/anie.201301813 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.45 Å) |
Structure validation
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