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4KAP

The Binding of Benzoarylsulfonamide Ligands to Human Carbonic Anhydrase is Insensitive to Formal Fluorination of the Ligand

Summary for 4KAP
Entry DOI10.2210/pdb4kap/pdb
DescriptorCarbonic anhydrase 2, ZINC ION, 4,5,6,7-tetrafluoro-1,3-benzothiazole-2-sulfonamide, ... (4 entities in total)
Functional Keywordsalpha beta, lyase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm: P00918
Total number of polymer chains1
Total formula weight29331.31
Authors
Lange, H.,Lockett, M.R.,Breiten, B.,Heroux, A.,Sherman, W.,Rappoport, D.,Yau, P.O.,Snyder, P.W.,Whitesides, G.M. (deposition date: 2013-04-22, release date: 2013-07-10, Last modification date: 2024-02-28)
Primary citationLockett, M.R.,Lange, H.,Breiten, B.,Heroux, A.,Sherman, W.,Rappoport, D.,Yau, P.O.,Snyder, P.W.,Whitesides, G.M.
The Binding of Benzoarylsulfonamide Ligands to Human Carbonic Anhydrase is Insensitive to Formal Fluorination of the Ligand.
Angew.Chem.Int.Ed.Engl., 52:7714-7717, 2013
Cited by
PubMed: 23788494
DOI: 10.1002/anie.201301813
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.45 Å)
Structure validation

217705

数据于2024-03-27公开中

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