4KA2

Crystal structure of CD4-mimetic miniprotein M48U12 in complex with HIV-1 YU2 gp120

Summary for 4KA2

Entry DOI	10.2210/pdb4ka2/pdb
Related	2I5Y 2I60 4JZW 4JZZ 4K0A
Related PRD ID	PRD_001102
Descriptor	HIV-1 YU2 gp120, M48U12, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
Functional Keywords	viral protein-peptide complex, hiv-1, gp120, yu2, cd4 mimic, m48u12, viral protein-inhibitor complex, viral protein/inhibitor
Biological source	Human immunodeficiency virus 1 More
Total number of polymer chains	2
Total formula weight	46520.89
Authors	Acharya, P.,Kwong, P.D. (deposition date: 2013-04-21, release date: 2013-06-19, Last modification date: 2023-11-15)
Primary citation	Morellato-Castillo, L.,Acharya, P.,Combes, O.,Michiels, J.,Descours, A.,Ramos, O.H.,Yang, Y.,Vanham, G.,Arien, K.K.,Kwong, P.D.,Martin, L.,Kessler, P. Interfacial Cavity Filling To Optimize CD4-Mimetic Miniprotein Interactions with HIV-1 Surface Glycoprotein. J.Med.Chem., 56:5033-5047, 2013 Cited by PubMed: 23710622 DOI: 10.1021/jm4002988 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.79 Å)

Structure validation