4K9G
1.55 A Crystal Structure of Macrophage Migration Inhibitory Factor bound to ISO-66 and a related compound
Summary for 4K9G
Entry DOI | 10.2210/pdb4k9g/pdb |
Related | 1LJT |
Descriptor | Macrophage migration inhibitory factor, (4R,6Z)-6-(3-fluoro-4-hydroxyphenyl)-4-hydroxy-6-iminohexan-2-one, 1-[(5S)-3-(3-fluoro-4-hydroxyphenyl)-4,5-dihydro-1,2-oxazol-5-yl]propan-2-one, ... (6 entities in total) |
Functional Keywords | cytokine, secreted/endocytosed, isomerase |
Biological source | Homo sapiens (human) |
Cellular location | Secreted: P14174 |
Total number of polymer chains | 3 |
Total formula weight | 38328.91 |
Authors | Crichlow, G.V.,Al-Abed, Y.,Lolis, E.J. (deposition date: 2013-04-19, release date: 2014-09-24, Last modification date: 2023-09-20) |
Primary citation | Ioannou, K.,Cheng, K.F.,Crichlow, G.V.,Birmpilis, A.I.,Lolis, E.J.,Tsitsilonis, O.E.,Al-Abed, Y. ISO-66, a novel inhibitor of macrophage migration, shows efficacy in melanoma and colon cancer models. INT J ONCOL., 45:1457-1468, 2014 Cited by PubMed: 25050663DOI: 10.3892/ijo.2014.2551 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.55 Å) |
Structure validation
Download full validation report