4K9B
Structure of Ternary Complex of cGAS with dsDNA and Bound c[G(2 ,5 )pA(3 ,5 )p]
Summary for 4K9B
Entry DOI | 10.2210/pdb4k9b/pdb |
Descriptor | Cyclic GMP-AMP synthase, DNA-F, DNA-R, ... (8 entities in total) |
Functional Keywords | nucleotidyltransferase fold, transferase-dna complex, transferase/dna |
Biological source | Mus musculus (mouse) More |
Cellular location | Cytoplasm, cytosol: Q8C6L5 |
Total number of polymer chains | 3 |
Total formula weight | 53795.74 |
Authors | Gao, P.,Wu, Y.,Patel, D.J. (deposition date: 2013-04-19, release date: 2013-05-15, Last modification date: 2024-05-29) |
Primary citation | Gao, P.,Ascano, M.,Wu, Y.,Barchet, W.,Gaffney, B.L.,Zillinger, T.,Serganov, A.A.,Liu, Y.,Jones, R.A.,Hartmann, G.,Tuschl, T.,Patel, D.J. Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase. Cell(Cambridge,Mass.), 153:1094-1107, 2013 Cited by PubMed: 23647843DOI: 10.1016/j.cell.2013.04.046 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.26 Å) |
Structure validation
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