4K8U

Crystal structure of TRAF4 TRAF domain

4K8U の概要

• エントリーDOI: 10.2210/pdb4k8u/pdb
• 分子名称: TNF receptor-associated factor 4 (2 entities in total)
• 機能のキーワード: traf domain, traf fold, protein interaction, signaling molecule binding, signaling protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 68492.59

構造登録者

Park, H.H.,Yoon, J.H. (登録日: 2013-04-18, 公開日: 2014-01-15, 最終更新日: 2024-03-20)

主引用文献

Yoon, J.H.,Cho, Y.J.,Park, H.H.
Structure of the TRAF4 TRAF domain with a coiled-coil domain and its implications for the TRAF4 signalling pathway.
Acta Crystallogr.,Sect.D, 70:2-10, 2014

PubMed Abstract: The TNF receptor-associated factor (TRAF) proteins are structurally similar scaffold proteins that mediate between members of the TNF receptor (TNFR) family and downstream effector molecules such as kinases in the immune signalling pathway. Seven TRAFs have been identified, including TRAF4, which is a unique member that participates in many ontogenic processes, including nerve-system development. TRAFs commonly contain the TRAF domain, which mediates interaction with target receptors and effectors. As a first step towards elucidating the molecular mechanisms of the TRAF4-mediated signalling pathway, the first crystal structure of the human TRAF4 TRAF domain with a coiled-coil domain is reported at 2.3 Å resolution.

PubMed: 24419373
DOI: 10.1107/S139900471302333X

実験手法

X-RAY DIFFRACTION (2.302 Å)