4K7Q

Crystal Structure of AcrB Complexed with Linezolid at 3.5 Resolution

4K7Q の概要

• エントリーDOI: 10.2210/pdb4k7q/pdb
• 分子名称: Acriflavine resistance protein B, N-{[(5S)-3-(3-fluoro-4-morpholin-4-ylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide (2 entities in total)
• 機能のキーワード: inner membrane resistance-nodulation-cell division efflux pump, membrane protein-antibiotic complex, membrane protein/antibiotic
• 由来する生物種: Escherichia coli
• 細胞内の位置: Cell inner membrane ; Multi- pass membrane protein : P31224
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 114555.09

構造登録者

Hung, L.W.,Kim, H.B.,Murakami, S.,Gupta, G.,Kim, C.Y.,Terwilliger, T.C. (登録日: 2013-04-17, 公開日: 2013-07-03, 最終更新日: 2024-02-28)

主引用文献

Hung, L.W.,Kim, H.B.,Murakami, S.,Gupta, G.,Kim, C.Y.,Terwilliger, T.C.
Crystal structure of AcrB complexed with linezolid at 3.5 Angstrom resolution.
J.Struct.Funct.Genom., 14:71-75, 2013

PubMed Abstract: AcrB is an inner membrane resistance-nodulation-cell division efflux pump and is part of the AcrAB-TolC tripartite efflux system. We have determined the crystal structure of AcrB with bound Linezolid at a resolution of 3.5 Å. The structure shows that Linezolid binds to the A385/F386 loops of the symmetric trimer of AcrB. A conformational change of a loop in the bottom of the periplasmic cleft is also observed.

PubMed: 23673416
DOI: 10.1007/s10969-013-9154-x

実験手法

X-RAY DIFFRACTION (3.5 Å)