4K7P

Generation and Characterization of a Unique Reagent that Recognizes a Panel of Recombinant Human Monoclonal Antibody Therapeutics in the Presence of Endogenous Human IgG

Summary for 4K7P

Entry DOI	10.2210/pdb4k7p/pdb
Descriptor	antibody rhumAb6 Fab fragment light chain, antibody rhumAb6 Fab fragment heavy chain, antibody 10C4 Fab fragment heavy chain, ... (4 entities in total)
Functional Keywords	immunoglobulin, immune system
Biological source	Homo sapiens More
Total number of polymer chains	4
Total formula weight	95651.62
Authors	Eigenbrot, C.,Shia, S. (deposition date: 2013-04-17, release date: 2013-08-07, Last modification date: 2023-09-20)
Primary citation	Wang, X.,Quarmby, V.,Ng, C.,Chuntharapai, A.,Shek, T.,Eigenbrot, C.,Kelley, R.F.,Shia, S.,McCutcheon, K.,Lowe, J.,Leddy, C.,Coachman, K.,Cain, G.,Chu, F.,Hotzel, I.,Maia, M.,Wakshull, E.,Yang, J. Generation and characterization of a unique reagent that recognizes a panel of recombinant human monoclonal antibody therapeutics in the presence of endogenous human IgG. MAbs, 5:540-554, 2013 Cited by PubMed: 23774668 DOI: 10.4161/mabs.24822 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.95 Å)

Structure validation