4K69

Crystal Structure of Human Chymase in Complex with Fragment Linked Benzimidazolone Inhibitor: (3S)-3-{3-[(6-bromo-2-oxo-2,3-dihydro-1H-indol-4-yl)methyl]-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl}hexanoic acid

Summary for 4K69

Entry DOI	10.2210/pdb4k69/pdb
Related	3S0N 4K2Y 4K5Z 4K60
Descriptor	Chymase, ZINC ION, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
Functional Keywords	serine protease, glycosylated, mast cells, secreted, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	25816.21
Authors	Collins, B.K.,Padyana, A.K. (deposition date: 2013-04-15, release date: 2013-05-29, Last modification date: 2020-07-29)
Primary citation	Taylor, S.J.,Padyana, A.K.,Abeywardane, A.,Liang, S.,Hao, M.H.,De Lombaert, S.,Proudfoot, J.,Farmer, B.S.,Li, X.,Collins, B.,Martin, L.,Albaugh, D.R.,Hill-Drzewi, M.,Pullen, S.S.,Takahashi, H. Discovery of Potent, Selective Chymase Inhibitors via Fragment Linking Strategies. J.Med.Chem., 56:4465-4481, 2013 Cited by PubMed: 23659209 DOI: 10.1021/jm400138z PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation