4K60
Crystal Structure of Human Chymase in Complex with Fragment 6-bromo-1,3-dihydro-2H-indol-2-one
Summary for 4K60
Entry DOI | 10.2210/pdb4k60/pdb |
Related | 3S0N 4K2Y 4K5Z 4K69 |
Descriptor | Chymase, 2-acetamido-2-deoxy-beta-D-glucopyranose, ZINC ION, ... (5 entities in total) |
Functional Keywords | serine protease, glycosylated, mast cells, secreted, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 25490.52 |
Authors | Collins, B.K.,Padyana, A.K. (deposition date: 2013-04-15, release date: 2013-05-29, Last modification date: 2020-07-29) |
Primary citation | Taylor, S.J.,Padyana, A.K.,Abeywardane, A.,Liang, S.,Hao, M.H.,De Lombaert, S.,Proudfoot, J.,Farmer, B.S.,Li, X.,Collins, B.,Martin, L.,Albaugh, D.R.,Hill-Drzewi, M.,Pullen, S.S.,Takahashi, H. Discovery of Potent, Selective Chymase Inhibitors via Fragment Linking Strategies. J.Med.Chem., 56:4465-4481, 2013 Cited by PubMed: 23659209DOI: 10.1021/jm400138z PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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