4K5J

Structure of bovine endothelial nitric oxide synthase heme domain in complex with (S)-1,3-bis((2-amino-4-methylpyridin-6-yl)-methoxy)-butan-4-amine

Summary for 4K5J

Entry DOI	10.2210/pdb4k5j/pdb
Related	4K5D 4K5E 4K5F 4K5G 4K5H 4K5I 4K5K
Descriptor	Nitric oxide synthase, endothelial, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (8 entities in total)
Functional Keywords	nitric oxide synthase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Bos taurus (bovine)
Cellular location	Cell membrane : P29473
Total number of polymer chains	2
Total formula weight	102346.14
Authors	Li, H.,Poulos, T.L. (deposition date: 2013-04-14, release date: 2013-09-18, Last modification date: 2023-09-20)
Primary citation	Jing, Q.,Li, H.,Chreifi, G.,Roman, L.J.,Martasek, P.,Poulos, T.L.,Silverman, R.B. Chiral linkers to improve selectivity of double-headed neuronal nitric oxide synthase inhibitors. Bioorg.Med.Chem.Lett., 23:5674-5679, 2013 Cited by PubMed: 23993333 DOI: 10.1016/j.bmcl.2013.08.034 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.36 Å)

Structure validation