4K4O

The DNA Gyrase B ATP binding domain of Enterococcus faecalis in complex with a small molecule inhibitor

4K4O の概要

• エントリーDOI: 10.2210/pdb4k4o/pdb
• 分子名称: DNA gyrase subunit B, 6-fluoro-4-[(3aR,6aR)-hexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl]-N-methyl-2-[(2-methylpyrimidin-5-yl)oxy]-9H-pyrimido[4,5-b]indol-8-amine, TERTIARY-BUTYL ALCOHOL, ... (4 entities in total)
• 機能のキーワード: atp-binding, nucleotide-binding, topoisomerase, atp-binding domain, isomerase-isomerase inhibitor complex, cytosol, isomerase/isomerase inhibitor
• 由来する生物種: Enterococcus faecalis
• 細胞内の位置: Cytoplasm (By similarity): Q839Z1
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 24344.20

構造登録者

Bensen, D.C.,Akers-Rodriguez, S.,Lam, T.,Tari, L.W. (登録日: 2013-04-12, 公開日: 2014-01-15, 最終更新日: 2023-09-20)

• 主引用文献: Tari, L.W.,Bensen, D.C.,Finn, J.; A new class of type IIA topoisomerase inhibitors with broad-spectrum antibacterial activity; To be Published,

実験手法

X-RAY DIFFRACTION (1.3 Å)