4K3J

Crystal structure of Onartuzumab Fab in complex with MET and HGF-beta

Summary for 4K3J

• Entry DOI: 10.2210/pdb4k3j/pdb
• Related: 1SHY
• Descriptor: Hepatocyte growth factor, Hepatocyte growth factor beta chain, Onartuzumab Fab heavy chain, ... (6 entities in total)
• Functional Keywords: antibody, glycosylation, transferase-immune system-growth factor complex, transferase/immune system/growth factor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 135381.99

Authors

Ma, X.,Starovasnik, M.A. (deposition date: 2013-04-10, release date: 2013-08-28, Last modification date: 2023-09-20)

• Primary citation: Merchant, M.,Ma, X.,Maun, H.R.,Zheng, Z.,Peng, J.,Romero, M.,Huang, A.,Yang, N.Y.,Nishimura, M.,Greve, J.,Santell, L.,Zhang, Y.W.,Su, Y.,Kaufman, D.W.,Billeci, K.L.,Mai, E.,Moffat, B.,Lim, A.,Duenas, E.T.,Phillips, H.S.,Xiang, H.,Young, J.C.,Vande Woude, G.F.,Dennis, M.S.,Reilly, D.E.,Schwall, R.H.,Starovasnik, M.A.,Lazarus, R.A.,Yansura, D.G.; Monovalent antibody design and mechanism of action of onartuzumab, a MET antagonist with anti-tumor activity as a therapeutic agent.; Proc.Natl.Acad.Sci.USA, 110:E2987-E2996, 2013; PubMed: 23882082; DOI: 10.1073/pnas.1302725110

Experimental method

X-RAY DIFFRACTION (2.8 Å)